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Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

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363 Reduced activity and expression of the GLUT-1 transporter in the BBB suggest decreased glucose uptake and utilization by the brain, 360,363 which may further exacerbate cerebrovascular degeneration, BBB breakdown, and A pathology in models overexpressing APP, inducing neurodegeneration and cognitive deficits (Fig